BIO Elisa Izaurralde

Elisa Izaurralde

Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen De  |  CV

Elisa Izaurralde has pioneered studies of RNA nucleo-cytoplasmic transport and cytoplasmic RNA regulation.  Izaurralde research group’s goal at the Department of Biochemistry at the Max Planck Institute for Developmental Biology is the elucidation of the molecular mechanisms that regulate gene expression at the post-transcriptional level, using a combination of small-scale and functional genomic approaches. Their three main aims are (1) to build a comprehensive list of effectors and interaction networks for post-transcriptional pathways in order to understand how these pathways are connected with each other and with different cellular processes, (2) to determine the contribution of these post-transcriptional processes to gene expression on a global scale and to identify endogenous targets, and (3) to understand how the regulation of the endogenous targets leads to the complex phenotypes observed at the cellular and organism level when these pathways are perturbed. Recent insights include structural/functional analysis of the CCR4-NOT deadenylase complex and mechanisms of decapping enzyme activation.

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