BIO Patrick Cramer

PATRICK CRAMER  

Max Planck Institute for Biophysical Chemistry, Göttingen DE  | CV

Patrick Cramer, from the Max Planck Institute for Biophysical Chemistry, has made seminal contributions to our understanding of the structural basis of RNA polymerase function. His lab currently follows two major routes. First, they use structural biology and complementary functional assays to elucidate the mechanisms of gene transcription in eukaryotic cells. Second, they develop functional genomics techniques to study the principles of gene regulation on a systems level. These two major efforts complement each other and help to develop the field of molecular systems biology. Recent highlights include transcriptome surveillance by selective termination of noncoding RNA synthesis, impairment of termination factor recruitment to RNA pol II by XTD tyrosine phosphorylation and the structure of the mediator head module.

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