https://2015symposium.crg.eu Barcelona 22-23 October Fri, 18 Dec 2015 08:33:54 +0000 en-US hourly 1 http://wordpress.org/?v=3.9.1 https://2015symposium.crg.eu/resolving-the-building-blocks-and-assembly-principles-of-cell-adhesion-machineries/?utm_source=rss&utm_medium=rss&utm_campaign=resolving-the-building-blocks-and-assembly-principles-of-cell-adhesion-machineries https://2015symposium.crg.eu/resolving-the-building-blocks-and-assembly-principles-of-cell-adhesion-machineries/#comments Thu, 22 Oct 2015 11:15:02 +0000 http://2015symposium.crg.eu/?p=771 Short Talk by Eli ZAMIR, from theDepartment of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund DE, about how  adhesion sites get self-assembled and function.

• Adhesion sites contain hundred different proteins called integrin adhesome. This proteins interact with each other, self-organizing as diverse adhesion sites with distinct properties
• Studies have been carried out about this self assembly, investigating the state of the integrin adhesome network in the cytosol and space and time relations with focal adhesions
• Using FCCS and FRAP measurements, it was found that cytosol complexes correlate with the internal organization: integrin adhesome is extensively pre-assembled in the cytosol, forming multi-protein building blocks for adhesion sites that are combinatorially diversified, and they correlate with the structural and functional organization of proteins across focal adhesions.
• Building blocks enter and exit this focal adhesions without being altered, preserving specifications and assembly logic. They are currently investigating the recruitment of specific multi-protein blocs to focal adhesions and its regulation to decipher this assembly logic. 

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